The latest research study on the effectiveness of Isomaltulose versus Sucrose in regulating endothelial function in overweight adults has been recently released in the prestigious journal Nutrients.
About this publication
The paper was based on a clinical study designed and conducted by Atlantia Clinical Trials, at our Cork facility, in Ireland. In this double‐blinded study, both source data and primary data analysis generation were provided by Atlantia Clinical Trials. The statistical analyses of this publication have been developed for the Sponsor, the exclusive of the project. The sponsor reserves the exclusive right to use the results and data for possible Health Claim requests.
Nutrients (ISSN 2072-6643; CODEN: NUTRHU) is a peer-reviewed open access journal of human nutrition published monthly online by MDPI.
The Asia Pacific Nutrigenomics Nutrigenetics Organisation (APNNO), Italian Society for Paediatric Nutrition and Gastroenterology (SIGENP), Nutrition Society of New Zealand (NSNZ), The Nutrition Society of Australia (NSA), International Chair for Advanced Studies on Hydration (CIEAH) and more societies are affiliated with Nutrients and their members receive a discount on article processing charges.
Nutrients is ranked 16th of 86 in the category 'Nutrition & Dietetics' by Clarivate Analytics. It received an updated Journal Impact Factor of 4.171 in the recent release of the Journal Citation Reports®. The journal's 5-Year Impact Factor is 4.813.
About this FMD clinical trial
This human clinical study aimed to bring to the market a low‐GI carbohydrate which could act as a sugar replacer, which may contribute to improved cardiovascular health. The main research objectives of this study were:
• To assess the effect of investigational product, relative to placebo, on change in postprandial flow mediated dilation (FMD).
• To investigate the effect of investigational product, relative to placebo in healthy subjects with mild hypertension on changes in Blood glucose concentrations and Insulin concentrations.
The exploratory study aimed to investigate the acute effects of the investigational product versus those of placebo on endothelium‐dependent vasodilation, i.e., FMD, in overweight/obese subjects.
The trial results
The findings show that the investigational product, compared to placebo, led to a better preservation of the basal, pre‐prandial, endothelial function in the postprandial phase. Particularly, persons with impaired insulin sensitivity seemed to benefit from the slow‐release carbohydrate of the investigational product. Replacing sugar with the investigational product may exert beneficial effects on cardiovascular health as a result of the more balanced and sustained blood glucose profile. The Sponsor has declared that the impact of continued investigational product consumption on endothelial function merits further research.
Atlantia Clinical Trials were delighted to take on the task of completing this trial efficiently, on budget on time. Our clinical research team appreciated the acknowledgement by the sponsors of the trial on the publication.
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