Hyperglycemia is linked to impaired arterial endothelial function (EF), an early sign of cardiovascular disease. We compared the efficacy of low‐glycaemic index isomaltose (Palatinose™)with that of sucrose in modulating EF, as assessed by flow‐mediated dilation (FMD). In this double‐blinded cross‐over study, 80 overweight mildly hypertensive subjects were randomized to receive50 g of either isomaltose or sucrose. On two non‐consecutive days, brachial artery ultrasound FMD scans were obtained prior to and hourly (T0–T3) after carbohydrate load. Blood was drawn immediately after scanning. Glucose and insulin levels were analyzed. Overall, the FMD decrease was attenuated by isomaltose compared to sucrose (ΔFMD = −0.003% and −0.151%; p > 0.05 for the interaction treatment x period). At T2, FMD was significantly higher after isomaltose administration compared to that after sucrose administration (FMD = 5.9 ± 2.9% and 5.4 ± 2.6%, p =0.047). Pearson correlations between FMD and blood glucose showed a trend for a negative association at T0 and T2 independently of the carbohydrate (r‐range = −0.20 to −0.23, p < 0.1). Sub‐analysis suggested a lower FMD in insulin‐resistant (IR) compared to insulin‐sensitive subjects. Isomaltose attenuated the postprandial decline of FMD, particularly in IR persons. These data support the potential of isomaltose to preserve the endothelial function postprandially and consequently play a favourable role in cardiovascular health.
In our study, we evaluated the efficacy of isomaltose (Palatinose™) and sucrose loads on endothelial function as assessed by brachial ultrasound flow‐mediated dilation. Our findings show that low‐GI isomaltose, compared to sucrose, led to a better preservation of the basal, pre‐prandial, endothelial function in the postprandial phase. Particularly, persons with impaired insulin sensitivity seemed to benefit from the slow‐release carbohydrate isomaltose. Replacing sugar with isomaltose may exert beneficial effects on cardiovascular health as a result of the more balanced and sustained blood glucose profile. The impact of continued isomaltose consumption on endothelial function merits further investigations.
Read the full publication
Sponsor & Volunteer Testimonials
“Extremely impressed on delivery of project... ”
“Updates were relevant and timely, I never felt that I wasnt informed properly. Extremely impressed on delivery of project during the COVID-19 pandemic. Clearly a lot of effort and work has been put in to making sure operations have been running as close to perfect as possible.”
- Nutrition Scientist at the largest producer of dairy products in Scandinavia
“very flexible and responsive, very transparent..."
"High quality work, expertise in nutritional intervention studies, very flexible and responsive, very transparent. Atlantia has a personal touch which makes working with you a lot of fun. It was assuring and great to see that the leadership are very knowledgeable and still very much involved in details of the work".
- Nutrition Manager at a global leader in collagen-based solutions
“Adaptability with trial design and inputs is great!"
"Adaptability with trial design and inputs is great! I expect them to be able to answer the questions I have and they always do."
- Head of Clinical and Regulatory Affairs at revolutionary company tackling diabetes, heart disease, and obesity
“I trust Atlantia in their capabilities...”
"I was satisfied of the service provided and I trust Atlantia in their capabilities to conduct successfully clinical trials. We have good previous experience together and I know Atlantia is always improving".
- Nutrition Research Manager at multinational functional ingredients company tackling bone health
“...expertise, way of working and customer friendliness... ”
"We expected (and got) solution-orientated answers in a suitable time frame, we appreciated the overall service of Atlantia (including the expertise, way of working and customer friendliness)"
- Nutrition Scientist at multinational functional ingredients company tackling body composition
“This disease would of taken another few years to diagnose...”
"Really great people to deal with!!! I have done a few trials and have found them exceptional at what they do. I completed a pill camera trial about 2 years ago. From doing so it was found I had Crohn's disease. This disease would of taken another few years to diagnose had I not done this trial."
- Volunteer who help us and took part in our Video Camera Endoscopy trial
“...very professional and friendly..."
"All the staff I have met have been very professional and friendly and the trials have been interesting, educational and ultimately beneficial to my health".
-Participant member of our volunteer database for trials
“...everything was explained perfectly”
"Very friendly staff and everything was explained perfectly, also they had to take bloods and I'm the biggest baby when it comes to needles, but I didn't even realise they were finished, they were that good."
-Volunteer who took part in our food bioavailability studies
“... treated me with respect ...”
"I thought that that the staff at Atlantia always treated me with the utmost respect and my health was always at the forefront."
-Member of our participant database who took part in multiple studies
Media & Resources
More From Atlantia
Our team has put together these clinical trial case studies in multiple topics to help you understand how we have assisted other sponsors in the past to tailor their clinical research programs.Read More
Many of our clinical studies conducted are translated to published research papers in some of the top nutrition journals. You can discover our latest published work under this section.Read More