Skip to content
envelope-open icon

sales@atlantiatrials.com

Publication

Direct Supplementation with Urolithin A Overcomes Limitations of Dietary Exposure and Gut Microbiome Variability

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

Share this publication on your network:
Direct Supplementation

Publication Overview

Urolithin A (UA) is produced by gut microflora from foods rich in ellagitannins. UA has been shown to improve mitochondrial health preclinically and in humans. Not everyone has a microbiome capable of producing UA, making supplementation with UA an appealing strategy. This is the first detailed investigation of the prevalence of UA producers in a healthy population and the ability of direct UA supplementation to overcome both microbiome and dietary variability. Dietary intake of a glass of pomegranate juice (PJ) was used to assess UA producer status (n = 100 participants) and to characterize differences in gut microbiome between UA producers from non-producers.

Publication Results

Subjects were randomized (1:1) to either PJ or a food product containing UA (500 mg). Prevalence of UA producers and non-producers were determined in the PJ group. Diet questionnaires and fecal samples were collected to compare differences between UA producers and non-producers along with plasma samples at different time points to assess levels of UA and its conjugates between the interventions. Only 12% of subjects had detectable levels of UA at baseline. Following PJ intake ~40% of the subjects converted significantly the precursor compounds into UA. UA producers were distinguished by a significantly higher gut microbiome diversity and ratio of Firmicutes to Bacteroides. Direct supplementation with UA significantly increased plasma levels and provided a >6-fold exposure to UA vs. PJ (p < 0.0001).Conclusions Differences in gut microbiome and diet that dictate natural exposure to UA can be overcome via direct dietary UA supplementation.

Direct Supplementation
Publication

Read the full publication

Sponsor & Volunteer Testimonials

Testimonial Delivery Clinical Project
“Extremely impressed on delivery of project... ”

“Updates were relevant and timely, I never felt that I wasnt informed properly. Extremely impressed on delivery of project during the COVID-19 pandemic. Clearly a lot of effort and work has been put in to making sure operations have been running as close to perfect as possible.”

- Nutrition Scientist at the largest producer of dairy products in Scandinavia
Testimonial  Flexible
“very flexible and responsive, very transparent..."

"High quality work, expertise in nutritional intervention studies, very flexible and responsive, very transparent. Atlantia has a personal touch which makes working with you a lot of fun. It was assuring and great to see that the leadership are very knowledgeable and still very much involved in details of the work".

- Nutrition Manager at a global leader in collagen-based solutions
Testimonial Trial Questions
“Adaptability with trial design and inputs is great!"

"Adaptability with trial design and inputs is great!  I expect them to be able to answer the questions I have and they always do."

- Head of Clinical and Regulatory Affairs at revolutionary company tackling diabetes, heart disease, and obesity
Testimonial Capabilities
“I trust Atlantia in their capabilities...”

"I was satisfied of the service provided and I trust Atlantia in their capabilities to conduct successfully clinical trials. We have good previous experience together and I know Atlantia is always improving".

- Nutrition Research Manager at multinational functional ingredients company tackling bone health
Testimonial Expertise
“...expertise, way of working and customer friendliness... ”

"We expected (and got) solution-orientated answers in a suitable time frame, we appreciated the overall service of Atlantia (including the expertise, way of working and customer friendliness)"

- Nutrition Scientist at multinational functional ingredients company tackling body composition
Testimonial Diagnosis
“This disease would of taken another few years to diagnose...”

"Really great people to deal with!!! I have done a few trials and have found them exceptional at what they do. I completed a pill camera trial about 2 years ago. From doing so it was found I had Crohn's disease. This disease would of taken another few years to diagnose had I not done this trial."

- Volunteer who help us and took part in our Video Camera Endoscopy trial
Testimonial Friendly
“...very professional and friendly..."

"All the staff I have met have been very professional and friendly and the trials have been interesting, educational and ultimately beneficial to my health".​

-Participant member of our volunteer database for trials
Testimonial Trial Explained
“...everything was explained perfectly”

"Very friendly staff and everything was explained perfectly, also they had to take bloods and I'm the biggest baby when it comes to needles, but I didn't even realise they were finished, they were that good."

-Volunteer who took part in our food bioavailability studies
Testimonial Trial Respect
“... treated me with respect ...”

"I thought that that the staff at Atlantia always treated me with the utmost respect and my health was always at the forefront."

-Member of our participant database who took part in multiple studies
Media & Resources

More From Atlantia

Case Studies

Case Studies

Our team has put together these clinical trial case studies in multiple topics to help you understand how we have assisted other sponsors in the past to tailor their clinical research programs.

Read More
Latest News

Latest News

Learn more about our company through our latest news. Articles have been worked on by members of our team. For media inquiries, please reach out to: marketing@atlantiatrials.com

Read More
Publications

Publications

Many of our clinical studies conducted are translated to published research papers in some of the top nutrition journals. You can discover our latest published work under this section.

Read More