Skin Research Techniques and Endpoints

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What Atlantia offer

Atlantia Clinical Trials has extensive experience in conducting clinical trials in skin health and the skin microbiome. Assessments include Transepidermal Water Loss (TEWL), hydration, and wrinkles.

We have conducted a large number of trials on a variety of investigational products including cosmeceuticals, nutricosmetics, probiotics, prebiotics, oils, and fatty acids.

Our expert research team will work with sponsor(s) to design and conduct a study most suitable for their IP, agreeing and applying the most suitable diagnostics.

We can statistically power your study to ensure that your objectives are achieved and reported in accordance with Regulatory guidelines.

At Atlantia we assess changes in skin parameters with both objective and subjective assessments:

Measurements & Indications

Skin Health Assessment (SUBJECTIVE)
Overall Dry Skin (Xerosis) Score (ODS): 5 point clinical assessment of skin dryness
5-Dimension (Degree, Duration, Direction, Disability & Distribution) Itch Scale: measure of pruritis
WHO-Five Well-being Index (WHO-5): self-reported measure of current mental wellbeing
Skin Tear Audit Research (STAR) classification system: clinical assessment of presence of skin tears
Richards-Campbell Sleep Questionnaire (RCSQ): self-assessment of sleep quality
Dietary Analysis: FFQ, 3 day diary
Skin Health Assessment (OBJECTIVE)
Epidermal Hydration: Corneometer
Transepidermal Water Loss (TEWL): Tewameter
Skin Surface pH: Skin pH Meter
Skin topography (wrinkles, texture, pores): Antera 3D Camera
Skin pigmentation (melanin, redness): Antera 3D Camera
Skin Elasticity: Cutometer
Profiling of skin microbiota: Sequencing, Transcriptomics, Functional Genomics, Flow Cytometry, PCR
Profiling of skin lipids: Lipidomics


Scientific Background

The human skin is the largest organ of the body with functions that include sensation, temperature regulation, water conservation, vitamin D synthesis and immunological surveillance. It is also the single most important determinant of human appearance, genetic heritage and identity. It is not surprising, therefore, that any impairment or disease of the skin has a profound impact on the general health, well-being and self-respect of an individual.

Factors that affect the health of skin include age, genetics, environment (photodamage, air pollution) and lifestyle (smoking, stress, alcohol and nutrition). In addition, the skin’s microbiome is extremely important; the “mutualistically symbiotic” microbes that make up part of the skin barrier, together with a person’s innate immunity, combine to form a delicate balance needed to maintain healthy skin. If this balance is disturbed, the host becomes more susceptible to inflammatory diseases and cutaneous infections. It is suggested that microbiota diversity alone can predict whether skin is healthy or not.

Whether you would like to conduct research into the efficacy of an active ingredient or perform final product claims testing, Atlantia can design the right study for you.

Our team can guide you in creating the right study design to support your research program

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